diff --git a/webob/response.py b/webob/response.py
index af1f902..0b21d68 100644
--- a/webob/response.py
+++ b/webob/response.py
@@ -997,7 +997,7 @@ class Response(object):
         """
         if body is None:
             body = self.body
-        md5_digest = md5(body).digest()
+        md5_digest = md5(body, usedforsecurity=False).digest()
         md5_digest = b64encode(md5_digest)
         md5_digest = md5_digest.replace(b'\n', b'')
         md5_digest = native_(md5_digest)