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diff --git a/webob/response.py b/webob/response.py
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index af1f902..0b21d68 100644
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--- a/webob/response.py
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+++ b/webob/response.py
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@@ -997,7 +997,7 @@ class Response(object):
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         """
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         if body is None:
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             body = self.body
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-        md5_digest = md5(body).digest()
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+        md5_digest = md5(body, usedforsecurity=False).digest()
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         md5_digest = b64encode(md5_digest)
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         md5_digest = md5_digest.replace(b'\n', b'')
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         md5_digest = native_(md5_digest)