diff --git a/valgrind-3.17.0-ppc64-pstxvp.patch b/valgrind-3.17.0-ppc64-pstxvp.patch
new file mode 100644
index 0000000..1253d00
--- /dev/null
+++ b/valgrind-3.17.0-ppc64-pstxvp.patch
@@ -0,0 +1,27 @@
+commit a7216a4c4cc676e8f4750e71e7de654c0ce78ca3
+Author: Will Schmidt <will_schmidt@vnet.ibm.com>
+Date:   Tue Aug 24 13:18:11 2021 -0500
+
+    Remove a unneeded / unnecessary prefix check.
+
+diff --git a/VEX/priv/guest_ppc_toIR.c b/VEX/priv/guest_ppc_toIR.c
+index f223fe9456..57ac7bcf48 100644
+--- a/VEX/priv/guest_ppc_toIR.c
++++ b/VEX/priv/guest_ppc_toIR.c
+@@ -14561,16 +14561,10 @@ static Bool dis_fp_pair_prefix ( UInt prefix, UInt theInstr )
+ 
+       /* Endian aware prefixed load */
+       pDIP( is_prefix, "stxvp %u,%llu(%u)\n", XTp, immediate_val, rA_addr );
+       DIPp( is_prefix, ",%u", R );
+ 
+-      if ( R == 1 ) {
+-         vex_printf("Illegal instruction R = 1; pstxvp %u,%llu(%u)\n",
+-                    XTp, immediate_val, rA_addr );
+-         return False;
+-      }
+-
+       assign( EA_8, binop( Iop_Add64, mkU64( 8 ), mkexpr( EA ) ) );
+       assign( EA_16, binop( Iop_Add64, mkU64( 16 ), mkexpr( EA ) ) );
+       assign( EA_24, binop( Iop_Add64, mkU64( 24 ), mkexpr( EA ) ) );
+ 
+       if (host_endness == VexEndnessBE) {
diff --git a/valgrind.spec b/valgrind.spec
index fbe4607..8c62bcf 100644
--- a/valgrind.spec
+++ b/valgrind.spec
@@ -169,6 +169,9 @@ Patch19: valgrind-3.17.0-vgdb-queued-signals.patch
 # KDE#440906 update test_isa_3_1_common.c to avoid modulo against hard regs
 Patch20: valgrind-3.17.0-ppc64-test-isa-3-1.patch
 
+# KDE#441512 remove troublesome block of code from guest_ppc_toIR for pstxvp
+Patch21: valgrind-3.17.0-ppc64-pstxvp.patch
+
 BuildRequires: make
 BuildRequires: glibc-devel
 
@@ -328,6 +331,7 @@ touch memcheck/tests/s390x/vistr.stdout.exp
 %patch18 -p1
 %patch19 -p1
 %patch20 -p1
+%patch21 -p1
 
 %build
 # LTO triggers undefined symbols in valgrind.  Valgrind has a --enable-lto
@@ -556,6 +560,7 @@ fi
 * Wed Aug 25 2021 Mark Wielaard <mjw@fedoraproject.org>
 - Add valgrind-3.17.0-vgdb-queued-signals.patch
 - Add valgrind-3.17.0-ppc64-test-isa-3-1.patch
+- Add valgrind-3.17.0-ppc64-pstxvp.patch
 
 * Fri Aug  6 2021 Mark Wielaard <mjw@fedoraproject.org> - 3.17.0-11
 - Add valgrind-3.17.0-ppc64-statfs64.patch