diff --git a/valgrind-3.14.0-ppc64-unaligned-vecs.patch b/valgrind-3.14.0-ppc64-unaligned-vecs.patch
new file mode 100644
index 0000000..00c64fc
--- /dev/null
+++ b/valgrind-3.14.0-ppc64-unaligned-vecs.patch
@@ -0,0 +1,28 @@
+commit 321771ee63740333ad355244e0764295218843b8
+Author: Mark Wielaard <mark@klomp.org>
+Date:   Sun Dec 9 14:26:39 2018 +0100
+
+    memcheck: Allow unaligned loads of 128bit vectors on ppc64[le].
+    
+    On powerpc partial unaligned loads of vectors from partially invalid
+    addresses are OK and could be generated by our translation of lxvd2x.
+    
+    Adjust partial_load memcheck tests to allow partial loads of 16 byte
+    vectors on powerpc64.
+    
+    Part of resolving bug #386945.
+
+diff --git a/memcheck/mc_main.c b/memcheck/mc_main.c
+index 737f79d..101916b 100644
+--- a/memcheck/mc_main.c
++++ b/memcheck/mc_main.c
+@@ -1354,6 +1354,9 @@ void mc_LOADV_128_or_256_slow ( /*OUT*/ULong* res,
+    tl_assert(szB == 16); // s390 doesn't have > 128 bit SIMD
+    /* OK if all loaded bytes are from the same page. */
+    Bool alignedOK = ((a & 0xfff) <= 0x1000 - szB);
++#  elif defined(VGA_ppc64be) || defined(VGA_ppc64le)
++   /* lxvd2x might generate an unaligned 128 bit vector load.  */
++   Bool alignedOK = (szB == 16);
+ #  else
+    /* OK if the address is aligned by the load size. */
+    Bool alignedOK = (0 == (a & (szB - 1)));
diff --git a/valgrind.spec b/valgrind.spec
index 742df5c..6924a70 100644
--- a/valgrind.spec
+++ b/valgrind.spec
@@ -140,6 +140,7 @@ Patch18: valgrind-3.14.0-final_tidyup.patch
 Patch19: valgrind-3.14.0-ppc64-ldbrx.patch
 Patch20: valgrind-3.14.0-ppc64-unaligned-words.patch
 Patch21: valgrind-3.14.0-ppc64-lxvd2x.patch
+Patch22: valgrind-3.14.0-ppc64-unaligned-vecs.patch
 
 %if %{build_multilib}
 # Ensure glibc{,-devel} is installed for both multilib arches
@@ -294,6 +295,7 @@ Valgrind User Manual for details.
 %patch19 -p1
 %patch20 -p1
 %patch21 -p1
+%patch22 -p1
 
 %build
 CC=gcc
@@ -533,6 +535,7 @@ fi
 - Add valgrind-3.14.0-ppc64-ldbrx.patch
 - Add valgrind-3.14.0-ppc64-unaligned-words.patch
 - Add valgrind-3.14.0-ppc64-lxvd2x.patch
+- Add valgrind-3.14.0-ppc64-unaligned-vecs.patch
 
 * Sat Dec  1 2018 Mark Wielaard <mjw@fedoraproject.org> - 3.14.0.5
 - Add valgrind-3.14.0-wcsncmp.patch (#1645971)