diff --git a/valgrind-3.14.0-ppc64-lxvd2x.patch b/valgrind-3.14.0-ppc64-lxvd2x.patch
new file mode 100644
index 0000000..cf2aa0c
--- /dev/null
+++ b/valgrind-3.14.0-ppc64-lxvd2x.patch
@@ -0,0 +1,47 @@
+commit b7d65cab4f3e9a6f66a496e723e53ed736c4d2e7
+Author: Mark Wielaard <mark@klomp.org>
+Date:   Sun Dec 9 00:55:42 2018 +0100
+
+    Implement ppc64 lxvd2x as 128-bit load with double word swap for ppc64le.
+    
+    This makes it possible for memcheck to know which part of the 128bit
+    vector is defined, even if the load is partly beyond an addressable block.
+    
+    Partially resolves bug 386945.
+
+diff --git a/VEX/priv/guest_ppc_toIR.c b/VEX/priv/guest_ppc_toIR.c
+index a81dace..7af4973 100644
+--- a/VEX/priv/guest_ppc_toIR.c
++++ b/VEX/priv/guest_ppc_toIR.c
+@@ -20590,16 +20590,22 @@ dis_vx_load ( UInt theInstr )
+    }
+    case 0x34C: // lxvd2x
+    {
+-      IROp addOp = ty == Ity_I64 ? Iop_Add64 : Iop_Add32;
+-      IRExpr * high, *low;
+-      ULong ea_off = 8;
+-      IRExpr* high_addr;
++      IRExpr *t128;
+       DIP("lxvd2x %d,r%u,r%u\n", XT, rA_addr, rB_addr);
+-      high = load( Ity_I64, mkexpr( EA ) );
+-      high_addr = binop( addOp, mkexpr( EA ), ty == Ity_I64 ? mkU64( ea_off )
+-            : mkU32( ea_off ) );
+-      low = load( Ity_I64, high_addr );
+-      putVSReg( XT, binop( Iop_64HLtoV128, high, low ) );
++      t128 = load( Ity_V128, mkexpr( EA ) );
++
++      /* The data in the vec register should be in big endian order.
++         So if we just did a little endian load then swap around the
++         high and low double words. */
++      if (host_endness == VexEndnessLE) {
++         IRTemp high = newTemp(Ity_I64);
++         IRTemp low = newTemp(Ity_I64);
++         assign( high, unop(Iop_V128HIto64, t128) );
++         assign( low, unop(Iop_V128to64, t128) );
++         t128 = binop( Iop_64HLtoV128, mkexpr (low), mkexpr (high) );
++      }
++
++      putVSReg( XT, t128 );
+       break;
+    }
+    case 0x14C: // lxvdsx
diff --git a/valgrind.spec b/valgrind.spec
index 1a9a64e..742df5c 100644
--- a/valgrind.spec
+++ b/valgrind.spec
@@ -139,6 +139,7 @@ Patch18: valgrind-3.14.0-final_tidyup.patch
 # See also patches 10 to 16 (yes, there are this many...)
 Patch19: valgrind-3.14.0-ppc64-ldbrx.patch
 Patch20: valgrind-3.14.0-ppc64-unaligned-words.patch
+Patch21: valgrind-3.14.0-ppc64-lxvd2x.patch
 
 %if %{build_multilib}
 # Ensure glibc{,-devel} is installed for both multilib arches
@@ -292,6 +293,7 @@ Valgrind User Manual for details.
 %patch18 -p1
 %patch19 -p1
 %patch20 -p1
+%patch21 -p1
 
 %build
 CC=gcc
@@ -530,6 +532,7 @@ fi
 - Add valgrind-3.14.0-final_tidyup.patch
 - Add valgrind-3.14.0-ppc64-ldbrx.patch
 - Add valgrind-3.14.0-ppc64-unaligned-words.patch
+- Add valgrind-3.14.0-ppc64-lxvd2x.patch
 
 * Sat Dec  1 2018 Mark Wielaard <mjw@fedoraproject.org> - 3.14.0.5
 - Add valgrind-3.14.0-wcsncmp.patch (#1645971)