diff --git a/valgrind-3.8.1-s390_tsearch_supp.patch b/valgrind-3.8.1-s390_tsearch_supp.patch
new file mode 100644
index 0000000..04c78ca
--- /dev/null
+++ b/valgrind-3.8.1-s390_tsearch_supp.patch
@@ -0,0 +1,19 @@
+--- valgrind-3.8.1/glibc-2.X.supp.in.orig	2012-10-15 14:10:24.646984028 +0200
++++ valgrind-3.8.1/glibc-2.X.supp.in	2012-10-15 14:13:58.505147375 +0200
+@@ -213,6 +213,16 @@
+    obj:/*libc-@GLIBC_VERSION@*.so
+ }
+ 
++## ---------------------------------------------------------------------##
++# Workaround for Bug 308427 - s390 memcheck reports tsearch conditional
++# jump or move depends on uninitialized value.
++{
++   s390x-tsearch-node_t-red
++   Memcheck:Cond
++   fun:tsearch
++   obj:/*libc-@GLIBC_VERSION@*.so
++}
++
+ ##----------------------------------------------------------------------##
+ # MontaVista Linux 4.0.1 on ppc32
+ {
diff --git a/valgrind.spec b/valgrind.spec
index 459c640..a0a7a44 100644
--- a/valgrind.spec
+++ b/valgrind.spec
@@ -117,6 +117,10 @@ Patch26: valgrind-3.8.1-gdbserver_exit.patch
 # KDE#164485 - VG_N_SEGNAMES and VG_N_SEGMENTS are (still) too small
 Patch27: valgrind-3.8.1-aspacemgr_VG_N_SEGs.patch
 
+# KDE#308427 - s390 memcheck reports tsearch conditional jump or move
+#              depends on uninitialized value [workaround, suppression]
+Patch28: valgrind-3.8.1-s390_tsearch_supp.patch
+
 Obsoletes: valgrind-callgrind
 %ifarch x86_64 ppc64
 # Ensure glibc{,-devel} is installed for both multilib arches
@@ -242,6 +246,9 @@ touch ./none/tests/amd64/bmi.stderr.exp
 %patch25 -p1
 %patch26 -p1
 %patch27 -p1
+%ifarch s390x
+%patch28 -p1
+%endif
 
 # To suppress eventual automake warnings/errors
 rm -f gdbserver_tests/filter_gdb.orig
@@ -391,7 +398,7 @@ echo ===============END TESTING===============
 %endif
 
 %changelog
-* Sat Oct 13 2012 Mark Wielaard <mjw@redhat.com>
+* Mon Oct 15 2012 Mark Wielaard <mjw@redhat.com>
 - Add valgrind-3.8.1-x86_amd64_features-avx.patch (KDE#307285)
 - Add valgrind-3.8.1-gdbserver_tests-syscall-template-source.patch (KDE#307155)
 - Add valgrind-3.8.1-overlap_memcpy_filter.patch (KDE#307290)
@@ -401,6 +408,7 @@ echo ===============END TESTING===============
 - Add valgrind-3.8.1-filter_gdb.patch (KDE#308321)
 - Add valgrind-3.8.1-gdbserver_exit.patch (#862795, KDE#308341)
 - Add valgrind-3.8.1-aspacemgr_VG_N_SEGs.patch (#730303, KDE#164485)
+- Add valgrind-3.8.1-s390_tsearch_supp.patch (#816244, KDE#308427)
 
 * Fri Sep 20 2012 Mark Wielaard <mjw@redhat.com> 3.8.1-2
 - Add valgrind-3.8.1-gdbserver_tests-mcinvoke-ppc64.patch