diff --git a/valgrind-3.12.0-ppc64-isa-3_00.patch b/valgrind-3.12.0-ppc64-isa-3_00.patch
new file mode 100644
index 0000000..b1e9ed4
--- /dev/null
+++ b/valgrind-3.12.0-ppc64-isa-3_00.patch
@@ -0,0 +1,54 @@
+PPC64:  ISA 3.0 setup fixes.
+
+There is a typo in the configure.ac file that causes the HAS_ISA_3_00
+variable to not be set.
+
+The mask64 value is missing the HWCAPS bit for ISA3.0.
+bugzilla
+---
+ VEX/priv/guest_ppc_toIR.c | 2 +-
+ configure.ac              | 2 +-
+ 2 files changed, 2 insertions(+), 2 deletions(-)
+
+diff --git a/VEX/priv/guest_ppc_toIR.c b/VEX/priv/guest_ppc_toIR.c
+index 0d27389..6fede61 100644
+--- a/VEX/priv/guest_ppc_toIR.c
++++ b/VEX/priv/guest_ppc_toIR.c
+@@ -29122,7 +29122,7 @@ DisResult disInstr_PPC ( IRSB*        irsb_IN,
+ 
+    mask64 = VEX_HWCAPS_PPC64_V | VEX_HWCAPS_PPC64_FX
+             | VEX_HWCAPS_PPC64_GX | VEX_HWCAPS_PPC64_VX | VEX_HWCAPS_PPC64_DFP
+-            | VEX_HWCAPS_PPC64_ISA2_07;
++            | VEX_HWCAPS_PPC64_ISA2_07 | VEX_HWCAPS_PPC64_ISA3_0;
+ 
+    if (mode64) {
+       vassert((hwcaps_guest & mask32) == 0);
+diff --git a/configure.ac b/configure.ac
+index 587917b..4c3cc58 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -1537,7 +1537,7 @@ ac_asm_have_isa_3_00=no
+ AC_MSG_RESULT([no])
+ ])
+ 
+-AM_CONDITIONAL(HAS_ISA_3_00, test x$ac_asm_have_isa_3_00 = xyes \
++AM_CONDITIONAL(HAS_ISA_3_00, [test x$ac_asm_have_isa_3_00 = xyes \
+                              -a x$HWCAP_HAS_ISA_3_00 = xyes])
+ 
+ # Check for pthread_create@GLIBC2.0
+-- 
+1.8.3.1
+
+Only in valgrind-3.12.0: autom4te.cache
+diff -ur valgrind-3.12.0.orig/configure valgrind-3.12.0/configure
+--- valgrind-3.12.0.orig/configure	2016-12-16 16:52:17.101832444 +0100
++++ valgrind-3.12.0/configure	2017-03-28 23:38:32.997776458 +0200
+@@ -8122,7 +8122,7 @@
+ rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext
+ 
+  if test x$ac_asm_have_isa_3_00 = xyes \
+-                             -a x$HWCAP_HAS_ISA_3_00 = xyes]; then
++                             -a x$HWCAP_HAS_ISA_3_00 = xyes; then
+   HAS_ISA_3_00_TRUE=
+   HAS_ISA_3_00_FALSE='#'
+ else
diff --git a/valgrind.spec b/valgrind.spec
index 77c0edc..108e8ca 100644
--- a/valgrind.spec
+++ b/valgrind.spec
@@ -3,7 +3,7 @@
 Summary: Tool for finding memory management bugs in programs
 Name: %{?scl_prefix}valgrind
 Version: 3.12.0
-Release: 7%{?dist}
+Release: 8%{?dist}
 Epoch: 1
 License: GPLv2+
 URL: http://www.valgrind.org/
@@ -130,6 +130,9 @@ Patch18: valgrind-3.12.0-aarch64-syscalls.patch
 #            stxssp, lxsd, lxssp instructions
 Patch19: valgrind-3.12.0-powerpc-register-pair.patch
 
+# KDE#377478 PPC64: ISA 3.0 setup fixes
+Patch20: valgrind-3.12.0-ppc64-isa-3_00.patch
+
 %if %{build_multilib}
 # Ensure glibc{,-devel} is installed for both multilib arches
 BuildRequires: /lib/libc.so.6 /usr/lib/libc.so /lib64/libc.so.6 /usr/lib64/libc.so
@@ -258,6 +261,7 @@ Valgrind User Manual for details.
 %patch17 -p1
 %patch18 -p1
 %patch19 -p1
+%patch20 -p1
 
 %build
 # We need to use the software collection compiler and binutils if available.
@@ -451,8 +455,9 @@ echo ===============END TESTING===============
 %endif
 
 %changelog
-* Tue Mar 28 2017 Mark Wielaard <mjw@redhat.com>
+* Tue Mar 28 2017 Mark Wielaard <mjw@redhat.com> - 3.12.0-8
 - Add valgrind-3.12.0-powerpc-register-pair.patch
+- Add valgrind-3.12.0-ppc64-isa-3_00.patch
 
 * Sat Feb 18 2017 Mark Wielaard <mjw@redhat.com> - 3.12.0-7
 - Add valgrind-3.12.0-aarch64-syscalls.patch