diff --git a/webob/response.py b/webob/response.py

index af1f902..0b21d68 100644

--- a/webob/response.py

+++ b/webob/response.py

@@ -997,7 +997,7 @@ class Response(object):

         """

         if body is None:

             body = self.body

-        md5_digest = md5(body).digest()

+        md5_digest = md5(body, usedforsecurity=False).digest()

         md5_digest = b64encode(md5_digest)

         md5_digest = md5_digest.replace(b'\n', b'')

         md5_digest = native_(md5_digest)