diff --git a/SOURCES/macros.python-srpm b/SOURCES/macros.python-srpm
index f6f1db6..8401975 100644
--- a/SOURCES/macros.python-srpm
+++ b/SOURCES/macros.python-srpm
@@ -49,6 +49,20 @@
 # Alternatively, it can be overridden in spec (e.g. to "3.8") when building for alternate Python stacks.
 %python3_pkgversion 3
 
+# Define where Python wheels will be stored and the prefix of -wheel packages
+# - In Fedora we want wheel subpackages named e.g. `python-pip-wheel` that
+#   install packages into `/usr/share/python-wheels`. Both names are not
+#   versioned, because they're used by all Python 3 stacks.
+# - In RHEL we want wheel packages named e.g. `python3-pip-wheel` and
+#   `python3.11-pip-wheel` that install packages into similarly versioned
+#   locations. We want each Python stack in RHEL to have their own wheels,
+#   because the main python3 wheels (which we can't upgrade) will likely be
+#   quite old by the time we're adding new alternate Python stacks.
+# - In ELN we want to follow Fedora, because builds for ELN and Fedora rawhide
+#   need to be interoperable.
+%python_wheel_pkg_prefix python%{?rhel:%{!?eln:%{python3_pkgversion}}}
+%python_wheel_dir %{_datadir}/%{python_wheel_pkg_prefix}-wheels
+
 # === Macros for Build/Requires tags using Python dist tags ===
 # - https://fedoraproject.org/wiki/Changes/Automatic_Provides_for_Python_RPM_Packages
 # - These macros need to be in macros.python-srpm, because BuildRequires tags
diff --git a/SPECS/python-rpm-macros.spec b/SPECS/python-rpm-macros.spec
index bf7be70..4290cf0 100644
--- a/SPECS/python-rpm-macros.spec
+++ b/SPECS/python-rpm-macros.spec
@@ -1,6 +1,6 @@
 Name:           python-rpm-macros
 Version:        3.9
-Release:        42%{?dist}
+Release:        43%{?dist}
 Summary:        The common Python RPM macros
 URL:            https://src.fedoraproject.org/rpms/python-rpm-macros/
 
@@ -96,6 +96,10 @@ install -m 644 compileall2.py %{buildroot}%{_rpmconfigdir}/redhat/
 
 
 %changelog
+* Wed Aug 11 2021 Tomas Orsava <torsava@redhat.com> - 3.9-43
+- Define a new macros %%python_wheel_dir and %%python_wheel_pkg_prefix
+- Related: rhbz#1982668
+
 * Tue Aug 10 2021 Mohan Boddu <mboddu@redhat.com> - 3.9-42
 - Rebuilt for IMA sigs, glibc 2.34, aarch64 flags
   Related: rhbz#1991688