diff --git a/brp-python-bytecompile-compatibility-with-newer-pyth.patch b/brp-python-bytecompile-compatibility-with-newer-pyth.patch
new file mode 100644
index 0000000..ebe7230
--- /dev/null
+++ b/brp-python-bytecompile-compatibility-with-newer-pyth.patch
@@ -0,0 +1,46 @@
+From acbf558c486ee3518aca74045504f05872da4a58 Mon Sep 17 00:00:00 2001
+From: Lumir Balhar <lbalhar@redhat.com>
+Date: Tue, 26 Sep 2023 13:14:44 +0200
+Subject: [PATCH] brp-python-bytecompile compatibility with newer pythons
+
+---
+ scripts/brp-python-bytecompile | 8 ++++----
+ 1 file changed, 4 insertions(+), 4 deletions(-)
+
+diff --git a/scripts/brp-python-bytecompile b/scripts/brp-python-bytecompile
+index 4a9b49e..472bf10 100644
+--- a/scripts/brp-python-bytecompile
++++ b/scripts/brp-python-bytecompile
+@@ -58,7 +58,7 @@ EOF
+ # and below /usr/lib/python3.1/, we're targeting /usr/bin/python3.1
+ 
+ shopt -s nullglob
+-for python_libdir in `find "$RPM_BUILD_ROOT" -type d|grep -E "/usr/lib(64)?/python[0-9]\.[0-9]$"`;
++for python_libdir in `find "$RPM_BUILD_ROOT" -type d|grep -E "/usr/lib(64)?/python[0-9]\.[0-9]+$"`;
+ do
+ 	python_binary=/usr/bin/$(basename $python_libdir)
+ 	if [ "$python_binary" = "/usr/bin/python3.6" ]; then
+@@ -97,17 +97,17 @@ fi
+ 
+ # Figure out if there are files to be bytecompiled with the default_python at all
+ # this prevents unnecessary default_python invocation
+-find "$RPM_BUILD_ROOT" -type f -name "*.py" | grep -Ev "/bin/|/sbin/|/usr/lib(64)?/python[0-9]\.[0-9]|/usr/share/doc" || exit 0
++find "$RPM_BUILD_ROOT" -type f -name "*.py" | grep -Ev "/bin/|/sbin/|/usr/lib(64)?/python[0-9]\.[0-9]+|/usr/share/doc" || exit 0
+ 
+ # Generate normal (.pyc) byte-compiled files.
+-python_bytecompile "" $default_python "/bin/|/sbin/|/usr/lib(64)?/python[0-9]\.[0-9]|/usr/share/doc" "$RPM_BUILD_ROOT" "$depth" "/"
++python_bytecompile "" $default_python "/bin/|/sbin/|/usr/lib(64)?/python[0-9]\.[0-9]+|/usr/share/doc" "$RPM_BUILD_ROOT" "$depth" "/"
+ if [ $? -ne 0 -a 0$errors_terminate -ne 0 ]; then
+ 	# One or more of the files had a syntax error
+ 	exit 1
+ fi
+ 
+ # Generate optimized (.pyo) byte-compiled files.
+-python_bytecompile "-O" $default_python "/bin/|/sbin/|/usr/lib(64)?/python[0-9]\.[0-9]|/usr/share/doc" "$RPM_BUILD_ROOT" "$depth" "/"
++python_bytecompile "-O" $default_python "/bin/|/sbin/|/usr/lib(64)?/python[0-9]\.[0-9]+|/usr/share/doc" "$RPM_BUILD_ROOT" "$depth" "/"
+ if [ $? -ne 0 -a 0$errors_terminate -ne 0 ]; then
+ 	# One or more of the files had a syntax error
+ 	exit 1
+-- 
+2.41.0
+
diff --git a/rpm.spec b/rpm.spec
index f235765..b550fb4 100644
--- a/rpm.spec
+++ b/rpm.spec
@@ -32,7 +32,7 @@
 
 %global rpmver 4.14.3
 #global snapver rc2
-%global rel 26
+%global rel 27
 
 %global srcver %{version}%{?snapver:-%{snapver}}
 %global srcdir %{?snapver:testing}%{!?snapver:%{name}-%(echo %{version} | cut -d'.' -f1-2).x}
@@ -150,6 +150,8 @@ Patch1000: disable-python-extra.patch
 Patch1001: compile-with-Platform-Python-binary-where-relevant.patch
 # make unversioned %%__python an error unless explicitly overridden
 Patch1002: rpm-4.14.2-unversioned-python.patch
+# Make brp-python-bytecompile compatible with Python 3.10+
+Patch1003: brp-python-bytecompile-compatibility-with-newer-pyth.patch
 
 # Partially GPL/LGPL dual-licensed and some bits with BSD
 # SourceLicense: (GPLv2+ and LGPLv2+ with exceptions) and BSD 
@@ -699,6 +701,10 @@ make check || cat tests/rpmtests.log
 %doc doc/librpm/html/*
 
 %changelog
+* Tue Sep 26 2023 Lumír Balhar <lbalhar@redhat.com> - 4.14.4-27
+- Make brp-python-bytecompile script compatible with Python 3.10+
+Resolves: RHEL-6423
+
 * Mon Dec 19 2022 Florian Festi <ffesti@redhat.com> - 4.14.4-26
 - Add --nocompression to rpm2archive (#2129345)