diff --git a/doc/centpkg_man_page.py b/doc/centpkg_man_page.py
index edae454..aa6ec35 100644
--- a/doc/centpkg_man_page.py
+++ b/doc/centpkg_man_page.py
@@ -2,7 +2,7 @@
 import os
 import sys
 
-from six.moves.configparser import ConfigParser
+from configparser import ConfigParser
 
 if __name__ == '__main__':
     module_path = os.path.abspath(os.path.join(os.path.dirname(__file__), '..'))
diff --git a/setup.py b/setup.py
index 71b2ea1..8b20454 100644
--- a/setup.py
+++ b/setup.py
@@ -16,7 +16,7 @@ setup(
         'python-gitlab',
         'pycurl',
         'rpkg>=1.65',
-        'six',
     ],
     scripts=['src/bin/centpkg', 'src/bin/centpkg-sig'],
+    python_requires='>=3.6',
 )
diff --git a/src/centpkg/__main__.py b/src/centpkg/__main__.py
index c696c69..c0dd86c 100644
--- a/src/centpkg/__main__.py
+++ b/src/centpkg/__main__.py
@@ -17,7 +17,7 @@ import os
 import sys
 import logging
 
-import six.moves.configparser as ConfigParser
+from configparser import ConfigParser
 
 import pyrpkg
 import pyrpkg.utils
@@ -54,7 +54,7 @@ def main():
         sys.exit(1)
 
     # Setup a configuration object and read config file data
-    config = ConfigParser.SafeConfigParser()
+    config = ConfigParser()
     config.read(args.config)
     config.read(args.user_config)
 
diff --git a/src/centpkg/cli.py b/src/centpkg/cli.py
index 4b7f830..27d25e6 100755
--- a/src/centpkg/cli.py
+++ b/src/centpkg/cli.py
@@ -22,8 +22,8 @@ from centpkg.utils import config_get_safely, do_add_remote, do_fork
 import centpkg.utils
 from pyrpkg.cli import cliClient
 from pyrpkg import rpkgError
-from six.moves.urllib_parse import urlparse
-import six.moves.configparser as ConfigParser
+from urllib.parse import urlparse
+from configparser import ConfigParser
 
 import gitlab
 import json
@@ -147,7 +147,7 @@ class centpkgClient(cliClient):
         internal_config_file = "/etc/rpkg/centpkg_internal.conf"
         if os.path.exists(internal_config_file):
             # Get our internal only variables
-            cfg = ConfigParser.SafeConfigParser()
+            cfg = ConfigParser()
             cfg.read(internal_config_file)
             pp_api_url = config_get_safely(cfg, "centpkg.internal", 'pp_api_url')
             gitbz_query_url = config_get_safely(cfg, "centpkg.internal", 'gitbz_query_url')
@@ -242,7 +242,7 @@ class centpkgClient(cliClient):
 
                 else:
                     # Get our internal only variables
-                    cfg = ConfigParser.SafeConfigParser()
+                    cfg = ConfigParser()
                     cfg.read(internal_config_file)
                     pp_api_url = config_get_safely(cfg, "centpkg.internal", 'pp_api_url')
                     gitbz_query_url = config_get_safely(cfg, "centpkg.internal", 'gitbz_query_url')
diff --git a/src/centpkg/lookaside.py b/src/centpkg/lookaside.py
index 4c72c88..859ea8e 100644
--- a/src/centpkg/lookaside.py
+++ b/src/centpkg/lookaside.py
@@ -16,7 +16,6 @@ download path.
 import io
 import os
 import pycurl
-import six
 import sys
 
 from pyrpkg.errors import InvalidHashType, UploadError, LayoutError
@@ -257,12 +256,6 @@ class SIGLookasideCache(CGILookasideCache):
         # https://bugzilla.redhat.com/show_bug.cgi?id=1241059
         _name = utils.get_repo_name(name) if is_dist_git(os.getcwd()) else name
 
-        if six.PY2 and isinstance(filename, six.text_type):
-            filename = filename.encode('utf-8')
-
-        if six.PY2 and isinstance(self.branch, six.text_type):
-            self.branch = self.branch.encode('utf-8')
-
         post_data = [('name', _name),
                      ('%ssum' % self.hashtype, hash),
                      ('filename', filename)]
@@ -328,13 +321,6 @@ class SIGLookasideCache(CGILookasideCache):
         """
         filename = os.path.basename(filepath)
 
-        # As in remote_file_exists, we need to convert unicode strings to str
-        if six.PY2:
-            if isinstance(name, six.text_type):
-                name = name.encode('utf-8')
-            if isinstance(filepath, six.text_type):
-                filepath = filepath.encode('utf-8')
-
         if self.remote_file_exists(name, filename, hash):
             self.log.info("File already uploaded: %s", filepath)
             return
diff --git a/src/centpkg/utils.py b/src/centpkg/utils.py
index b201697..7438a96 100644
--- a/src/centpkg/utils.py
+++ b/src/centpkg/utils.py
@@ -20,8 +20,8 @@ import sys
 from datetime import date, datetime
 from pyrpkg import rpkgError
 from requests.exceptions import ConnectionError
-from six.moves.configparser import NoOptionError, NoSectionError
-from six.moves.urllib.parse import quote_plus, urlparse
+from configparser import NoOptionError, NoSectionError
+from urllib.parse import quote_plus, urlparse
 
 import git as gitpython